Poly-dipeptides encoded by the C9ORF72 repeats bind nucleoli, impede RNA biogenesis, and kill cells

Many RNA regulatory proteins controlling pre-mRNA splicing contain serine:arginine (SR) repeats. Here we found that these SR domains bound hydrogel droplets composed of fibrous polymers of the low-complexity domain of heterogeneous ribonucleoprotein A2 (hnRNPA2). Hydrogel binding was reversed upon p...

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Detalhes bibliográficos
Publicado no:Science
Main Authors: Kwon, Ilmin, Xiang, Siheng, Kato, Masato, Wu, Leeju, Theodoropoulos, Pano, Wang, Tao, Kim, Jiwoong, Yun, Jonghyun, Xie, Yang, McKnight, Steven L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4459787/
https://ncbi.nlm.nih.gov/pubmed/25081482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1254917
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