C9orf72-derived arginine-containing dipeptide repeats associate with axonal transport machinery and impede microtubule-based motility

A hexanucleotide repeat expansion in the C9orf72 gene is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). How this mutation leads to these neurodegenerative diseases remains unclear. Here, we show using patient stem cell–derived motor neurons th...

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Udgivet i:Sci Adv
Main Authors: Fumagalli, Laura, Young, Florence L., Boeynaems, Steven, De Decker, Mathias, Mehta, Arpan R., Swijsen, Ann, Fazal, Raheem, Guo, Wenting, Moisse, Matthieu, Beckers, Jimmy, Dedeene, Lieselot, Selvaraj, Bhuvaneish T., Vandoorne, Tijs, Madan, Vanesa, van Blitterswijk, Marka, Raitcheva, Denitza, McCampbell, Alexander, Poesen, Koen, Gitler, Aaron D., Koch, Philipp, Berghe, Pieter Vanden, Thal, Dietmar Rudolf, Verfaillie, Catherine, Chandran, Siddharthan, Van Den Bosch, Ludo, Bullock, Simon L., Van Damme, Philip
Format: Artigo
Sprog:Inglês
Udgivet: American Association for the Advancement of Science 2021
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8034861/
https://ncbi.nlm.nih.gov/pubmed/33837088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abg3013
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