C9orf72-derived arginine-containing dipeptide repeats associate with axonal transport machinery and impede microtubule-based motility

A hexanucleotide repeat expansion in the C9orf72 gene is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). How this mutation leads to these neurodegenerative diseases remains unclear. Here, we show using patient stem cell–derived motor neurons th...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Fumagalli, Laura, Young, Florence L., Boeynaems, Steven, De Decker, Mathias, Mehta, Arpan R., Swijsen, Ann, Fazal, Raheem, Guo, Wenting, Moisse, Matthieu, Beckers, Jimmy, Dedeene, Lieselot, Selvaraj, Bhuvaneish T., Vandoorne, Tijs, Madan, Vanesa, van Blitterswijk, Marka, Raitcheva, Denitza, McCampbell, Alexander, Poesen, Koen, Gitler, Aaron D., Koch, Philipp, Berghe, Pieter Vanden, Thal, Dietmar Rudolf, Verfaillie, Catherine, Chandran, Siddharthan, Van Den Bosch, Ludo, Bullock, Simon L., Van Damme, Philip
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2021
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8034861/
https://ncbi.nlm.nih.gov/pubmed/33837088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abg3013
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