Loading...
HDAC6 inhibition restores TDP‐43 pathology and axonal transport defects in human motor neurons with TARDBP mutations
TDP‐43 is the major component of pathological inclusions in most ALS patients and in up to 50% of patients with frontotemporal dementia (FTD). Heterozygous missense mutations in TARDBP, the gene encoding TDP‐43, are one of the common causes of familial ALS. In this study, we investigate TDP‐43 prote...
Saved in:
| Published in: | EMBO J |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
John Wiley and Sons Inc.
2021
|
| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8013789/ https://ncbi.nlm.nih.gov/pubmed/33694180 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2020106177 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|