HDAC6 inhibition restores TDP‐43 pathology and axonal transport defects in human motor neurons with TARDBP mutations

TDP‐43 is the major component of pathological inclusions in most ALS patients and in up to 50% of patients with frontotemporal dementia (FTD). Heterozygous missense mutations in TARDBP, the gene encoding TDP‐43, are one of the common causes of familial ALS. In this study, we investigate TDP‐43 prote...

Full description

Saved in:
Bibliographic Details
Published in:EMBO J
Main Authors: Fazal, Raheem, Boeynaems, Steven, Swijsen, Ann, De Decker, Mathias, Fumagalli, Laura, Moisse, Matthieu, Vanneste, Joni, Guo, Wenting, Boon, Ruben, Vercruysse, Thomas, Eggermont, Kristel, Swinnen, Bart, Beckers, Jimmy, Pakravan, Donya, Vandoorne, Tijs, Vanden Berghe, Pieter, Verfaillie, Catherine, Van Den Bosch, Ludo, Van Damme, Philip
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2021
Subjects:
Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8013789/
https://ncbi.nlm.nih.gov/pubmed/33694180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2020106177
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items