HDAC6 inhibition restores TDP‐43 pathology and axonal transport defects in human motor neurons with TARDBP mutations

TDP‐43 is the major component of pathological inclusions in most ALS patients and in up to 50% of patients with frontotemporal dementia (FTD). Heterozygous missense mutations in TARDBP, the gene encoding TDP‐43, are one of the common causes of familial ALS. In this study, we investigate TDP‐43 prote...

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Foilsithe in:EMBO J
Main Authors: Fazal, Raheem, Boeynaems, Steven, Swijsen, Ann, De Decker, Mathias, Fumagalli, Laura, Moisse, Matthieu, Vanneste, Joni, Guo, Wenting, Boon, Ruben, Vercruysse, Thomas, Eggermont, Kristel, Swinnen, Bart, Beckers, Jimmy, Pakravan, Donya, Vandoorne, Tijs, Vanden Berghe, Pieter, Verfaillie, Catherine, Van Den Bosch, Ludo, Van Damme, Philip
Formáid: Artigo
Teanga:Inglês
Foilsithe: John Wiley and Sons Inc. 2021
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Articles
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8013789/
https://ncbi.nlm.nih.gov/pubmed/33694180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2020106177
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