Differentiation but not ALS mutations in FUS rewires motor neuron metabolism

Energy metabolism has been repeatedly linked to amyotrophic lateral sclerosis (ALS). Yet, motor neuron (MN) metabolism remains poorly studied and it is unknown if ALS MNs differ metabolically from healthy MNs. To address this question, we first performed a metabolic characterization of induced pluri...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Vandoorne, Tijs, Veys, Koen, Guo, Wenting, Sicart, Adria, Vints, Katlijn, Swijsen, Ann, Moisse, Matthieu, Eelen, Guy, Gounko, Natalia V., Fumagalli, Laura, Fazal, Raheem, Germeys, Christine, Quaegebeur, Annelies, Fendt, Sarah-Maria, Carmeliet, Peter, Verfaillie, Catherine, Van Damme, Philip, Ghesquière, Bart, De Bock, Katrien, Van Den Bosch, Ludo
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6742665/
https://ncbi.nlm.nih.gov/pubmed/31515480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12099-4
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