Differentiation but not ALS mutations in FUS rewires motor neuron metabolism

Energy metabolism has been repeatedly linked to amyotrophic lateral sclerosis (ALS). Yet, motor neuron (MN) metabolism remains poorly studied and it is unknown if ALS MNs differ metabolically from healthy MNs. To address this question, we first performed a metabolic characterization of induced pluri...

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Pubblicato in:Nat Commun
Autori principali: Vandoorne, Tijs, Veys, Koen, Guo, Wenting, Sicart, Adria, Vints, Katlijn, Swijsen, Ann, Moisse, Matthieu, Eelen, Guy, Gounko, Natalia V., Fumagalli, Laura, Fazal, Raheem, Germeys, Christine, Quaegebeur, Annelies, Fendt, Sarah-Maria, Carmeliet, Peter, Verfaillie, Catherine, Van Damme, Philip, Ghesquière, Bart, De Bock, Katrien, Van Den Bosch, Ludo
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6742665/
https://ncbi.nlm.nih.gov/pubmed/31515480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12099-4
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