Mutant FUS causes DNA ligation defects to inhibit oxidative damage repair in Amyotrophic Lateral Sclerosis

Genome damage and defective repair are etiologically linked to neurodegeneration. However, the specific mechanisms involved remain enigmatic. Here, we identify defects in DNA nick ligation and oxidative damage repair in a subset of amyotrophic lateral sclerosis (ALS) patients. These defects are caus...

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Publicado no:Nat Commun
Main Authors: Wang, Haibo, Guo, Wenting, Mitra, Joy, Hegde, Pavana M., Vandoorne, Tijs, Eckelmann, Bradley J., Mitra, Sankar, Tomkinson, Alan E., Van Den Bosch, Ludo, Hegde, Muralidhar L.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6134028/
https://ncbi.nlm.nih.gov/pubmed/30206235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06111-6
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