C9orf72 poly(PR) Dipeptide Repeats Disturb Biomolecular Phase Separation and Disrupt Nucleolar Function

Repeat expansion in the C9orf72 gene is the most common cause of the neurodegenerative disorder amyotrophic lateral sclerosis (C9-ALS), and is linked to the unconventional translation of five dipeptide repeat polypeptides (DPRs). The two enriched in arginine, poly(GR) and poly(PR), infiltrate liquid...

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Publicat a:Mol Cell
Autors principals: White, Michael R., Mitrea, Diana M., Zhang, Peipei, Stanley, Christopher B., Cassidy, Devon E., Nourse, Amanda, Phillips, Aaron H., Tolbert, Michele, Taylor, J. Paul, Kriwacki, Richard W.
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6525025/
https://ncbi.nlm.nih.gov/pubmed/30981631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.03.019
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