Glycine-alanine dipeptide repeat protein contributes to toxicity in a zebrafish model of C9orf72 associated neurodegeneration

BACKGROUND: The most frequent genetic cause of frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) is the expansion of a GGGGCC hexanucleotide repeat in a non-coding region of the chromosome 9 open reading frame 72 (C9orf72) locus. The pathological hallmarks observed in...

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Détails bibliographiques
Publié dans:Mol Neurodegener
Auteurs principaux: Ohki, Yu, Wenninger-Weinzierl, Andrea, Hruscha, Alexander, Asakawa, Kazuhide, Kawakami, Koichi, Haass, Christian, Edbauer, Dieter, Schmid, Bettina
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2017
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5237533/
https://ncbi.nlm.nih.gov/pubmed/28088213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-016-0146-8
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