Antibodies inhibit transmission and aggregation of C9orf72 poly‐GA dipeptide repeat proteins

Cell‐to‐cell transmission of protein aggregates is an emerging theme in neurodegenerative disease. Here, we analyze the dipeptide repeat (DPR) proteins that form neuronal inclusions in patients with hexanucleotide repeat expansion C9orf72, the most common known cause of amyotrophic lateral sclerosis...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:EMBO Mol Med
Prif Awduron: Zhou, Qihui, Lehmer, Carina, Michaelsen, Meike, Mori, Kohji, Alterauge, Dominik, Baumjohann, Dirk, Schludi, Martin H, Greiling, Johanna, Farny, Daniel, Flatley, Andrew, Feederle, Regina, May, Stephanie, Schreiber, Franziska, Arzberger, Thomas, Kuhm, Christoph, Klopstock, Thomas, Hermann, Andreas, Haass, Christian, Edbauer, Dieter
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley and Sons Inc. 2017
Pynciau:
Research Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5412769/
https://ncbi.nlm.nih.gov/pubmed/28351931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201607054
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