Antibodies inhibit transmission and aggregation of C9orf72 poly‐GA dipeptide repeat proteins

Abstract Cell‐to‐cell transmission of protein aggregates is an emerging theme in neurodegenerative disease. Here, we analyze the dipeptide repeat (DPR) proteins that form neuronal inclusions in patients with hexanucleotide repeat expansion C9orf72, the most common known cause of amyotrophic lateral...

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Dettagli Bibliografici

Autori principali:	Qihui Zhou, Carina Lehmer, Meike Michaelsen, Kohji Mori, Dominik Alterauge, Dirk Baumjohann, Martin H Schludi, Johanna Greiling, Daniel Farny, Andrew Flatley, Regina Feederle, Stephanie May, Franziska Schreiber, Thomas Arzberger, Christoph Kuhm, Thomas Klopstock, Andreas Hermann, Christian Haass, Dieter Edbauer
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Springer Nature 2017-03-01
Serie:	EMBO Molecular Medicine
Soggetti:	amyotrophic lateral sclerosis C9orf72 immunotherapy RAN translation seeding
Accesso online:	https://doi.org/10.15252/emmm.201607054
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