Active poly‐GA vaccination prevents microglia activation and motor deficits in a C9orf72 mouse model

The C9orf72 repeat expansion is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and/or frontotemporal dementia (FTD). Non‐canonical translation of the expanded repeat results in abundant poly‐GA inclusion pathology throughout the CNS. (GA)(149)‐CFP expression in mice triggers mo...

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Publicat a:EMBO Mol Med
Autors principals: Zhou, Qihui, Mareljic, Nikola, Michaelsen, Meike, Parhizkar, Samira, Heindl, Steffanie, Nuscher, Brigitte, Farny, Daniel, Czuppa, Mareike, Schludi, Carina, Graf, Alexander, Krebs, Stefan, Blum, Helmut, Feederle, Regina, Roth, Stefan, Haass, Christian, Arzberger, Thomas, Liesz, Arthur, Edbauer, Dieter
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2019
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Reports
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7005532/
https://ncbi.nlm.nih.gov/pubmed/31858749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201910919
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