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Cell‐to‐cell transmission of C9orf72 poly‐(Gly‐Ala) triggers key features of ALS/FTD

The C9orf72 repeat expansion causes amyotrophic lateral sclerosis and frontotemporal dementia, but the poor correlation between C9orf72‐specific pathology and TDP‐43 pathology linked to neurodegeneration hinders targeted therapeutic development. Here, we addressed the role of the aggregating dipepti...

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Bibliografiske detaljer
Udgivet i:EMBO J
Main Authors: Khosravi, Bahram, LaClair, Kathrine D, Riemenschneider, Henrick, Zhou, Qihui, Frottin, Frédéric, Mareljic, Nikola, Czuppa, Mareike, Farny, Daniel, Hartmann, Hannelore, Michaelsen, Meike, Arzberger, Thomas, Hartl, F Ulrich, Hipp, Mark S, Edbauer, Dieter
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7156967/
https://ncbi.nlm.nih.gov/pubmed/32175624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2019102811
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