Proteomics and C9orf72 neuropathology identify ribosomes as poly-GR/PR interactors driving toxicity

Frontotemporal dementia and amyotrophic lateral sclerosis patients with C9orf72 mutation show cytoplasmic poly-GR and poly-PR aggregates. Short poly-(Gly-Arg) and poly-(Pro-Arg) (poly-GR/PR) repeats localizing to the nucleolus are toxic in various model systems, but no interactors have been validate...

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Detalhes bibliográficos
Publicado no:Life Sci Alliance
Main Authors: Hartmann, Hannelore, Hornburg, Daniel, Czuppa, Mareike, Bader, Jakob, Michaelsen, Meike, Farny, Daniel, Arzberger, Thomas, Mann, Matthias, Meissner, Felix, Edbauer, Dieter
Formato: Artigo
Idioma:Inglês
Publicado em: Life Science Alliance LLC 2018
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6238541/
https://ncbi.nlm.nih.gov/pubmed/30456350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.201800070
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