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Proteomics and C9orf72 neuropathology identify ribosomes as poly-GR/PR interactors driving toxicity
Frontotemporal dementia and amyotrophic lateral sclerosis patients with C9orf72 mutation show cytoplasmic poly-GR and poly-PR aggregates. Short poly-(Gly-Arg) and poly-(Pro-Arg) (poly-GR/PR) repeats localizing to the nucleolus are toxic in various model systems, but no interactors have been validate...
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| Yayımlandı: | Life Sci Alliance |
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| Asıl Yazarlar: | , , , , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Life Science Alliance LLC
2018
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6238541/ https://ncbi.nlm.nih.gov/pubmed/30456350 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.201800070 |
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