Reduced hnRNPA3 increases C9orf72 repeat RNA levels and dipeptide‐repeat protein deposition

Intronic hexanucleotide (G(4)C(2)) repeat expansions in C9orf72 are genetically associated with frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). The repeat RNA accumulates within RNA foci but is also translated into disease characterizing dipeptide repeat proteins (D...

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Detalhes bibliográficos
Publicado no:EMBO Rep
Main Authors: Mori, Kohji, Nihei, Yoshihiro, Arzberger, Thomas, Zhou, Qihui, Mackenzie, Ian R, Hermann, Andreas, Hanisch, Frank, Kamp, Frits, Nuscher, Brigitte, Orozco, Denise, Edbauer, Dieter, Haass, Christian
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5007570/
https://ncbi.nlm.nih.gov/pubmed/27461252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201541724
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