The Proline/Arginine Dipeptide from Hexanucleotide Repeat Expanded C9ORF72 Inhibits the Proteasome

An intronic hexanucleotide repeat expansion (HRE) mutation in the C9ORF72 gene is the most common cause of familial ALS and frontotemporal dementia (FTD) and is found in ∼7% of individuals with apparently sporadic disease. Several different diamino acid peptides can be generated from the HRE by nonc...

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Detalhes bibliográficos
Publicado no:eNeuro
Main Authors: Gupta, Rahul, Lan, Matthews, Mojsilovic-Petrovic, Jelena, Choi, Won Hoon, Safren, Nathaniel, Barmada, Sami, Lee, Min Jae, Kalb, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2017
Assuntos:
New Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5282547/
https://ncbi.nlm.nih.gov/pubmed/28197542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/ENEURO.0249-16.2017
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