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Yeast screen for modifiers of C9orf72 poly(glycine-arginine) dipeptide repeat toxicity

A hexanucleotide repeat expansion in the C9orf72 gene has been identified as the most common cause of amyotrophic lateral sclerosis and frontotemporal dementia. The expanded hexanucleotide repeat is translated by an unconventional mechanism to produce five species of dipeptide repeat (DPR) proteins,...

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Detalles Bibliográficos
Publicado en:FEMS Yeast Res
Autores principales: Chai, Noori, Gitler, Aaron D
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2018
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5946852/
https://ncbi.nlm.nih.gov/pubmed/29528392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/femsyr/foy024
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