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Type I PRMT Inhibition Protects Against C9ORF72 Arginine-Rich Dipeptide Repeat Toxicity

Repeat expansion mutations in the C9ORF72 gene are the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Repeat-associated non-AUG translation of this expansion produces dipeptide repeat proteins (DRPs). The arginine containing DRPs, polyGR and polyP...

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Bibliografiske detaljer
Udgivet i:Front Pharmacol
Main Authors: Premasiri, Alan S., Gill, Anna L., Vieira, Fernando G.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7508178/
https://ncbi.nlm.nih.gov/pubmed/33013410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.569661
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