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C9orf72 arginine-rich dipeptide repeat proteins disrupt karyopherin-mediated nuclear import

Disruption of nucleocytoplasmic transport is increasingly implicated in the pathogenesis of neurodegenerative diseases, including ALS caused by a C9orf72 hexanucleotide repeat expansion. However, the mechanism(s) remain unclear. Karyopherins, including importin β and its cargo adaptors, have been sh...

Täydet tiedot

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Bibliografiset tiedot
Julkaisussa:eLife
Päätekijät: Hayes, Lindsey R, Duan, Lauren, Bowen, Kelly, Kalab, Petr, Rothstein, Jeffrey D
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: eLife Sciences Publications, Ltd 2020
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7051184/
https://ncbi.nlm.nih.gov/pubmed/32119645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.51685
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