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C9orf72 arginine-rich dipeptide repeat proteins disrupt karyopherin-mediated nuclear import
Disruption of nucleocytoplasmic transport is increasingly implicated in the pathogenesis of neurodegenerative diseases, including ALS caused by a C9orf72 hexanucleotide repeat expansion. However, the mechanism(s) remain unclear. Karyopherins, including importin β and its cargo adaptors, have been sh...
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| 出版年: | eLife |
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| 主要な著者: | , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
eLife Sciences Publications, Ltd
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7051184/ https://ncbi.nlm.nih.gov/pubmed/32119645 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.51685 |
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