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C9orf72 arginine-rich dipeptide repeats inhibit UPF1-mediated RNA decay via translational repression
Expansion of an intronic (GGGGCC)(n) repeat region within the C9orf72 gene is a main cause of familial amyotrophic lateral sclerosis and frontotemporal dementia (c9ALS/FTD). A hallmark of c9ALS/FTD is the accumulation of misprocessed RNAs, which are often targets of cellular RNA surveillance. Here,...
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| Udgivet i: | Nat Commun |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group UK
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7335171/ https://ncbi.nlm.nih.gov/pubmed/32620797 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17129-0 |
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