DDX3X and specific initiation factors modulate FMR1 repeat‐associated non‐AUG‐initiated translation

A CGG trinucleotide repeat expansion in the 5′ UTR of FMR1 causes the neurodegenerative disorder Fragile X‐associated tremor/ataxia syndrome (FXTAS). This repeat supports a non‐canonical mode of protein synthesis known as repeat‐associated, non‐AUG (RAN) translation. The mechanism underlying RAN tra...

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Vydáno v:EMBO Rep
Hlavní autoři: Linsalata, Alexander E, He, Fang, Malik, Ahmed M, Glineburg, Mary Rebecca, Green, Katelyn M, Natla, Sam, Flores, Brittany N, Krans, Amy, Archbold, Hilary C, Fedak, Stephen J, Barmada, Sami J, Todd, Peter K
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6726903/
https://ncbi.nlm.nih.gov/pubmed/31347257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201847498
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