DDX3X and specific initiation factors modulate FMR1 repeat‐associated non‐AUG‐initiated translation

A CGG trinucleotide repeat expansion in the 5′ UTR of FMR1 causes the neurodegenerative disorder Fragile X‐associated tremor/ataxia syndrome (FXTAS). This repeat supports a non‐canonical mode of protein synthesis known as repeat‐associated, non‐AUG (RAN) translation. The mechanism underlying RAN tra...

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Pubblicato in:EMBO Rep
Autori principali: Linsalata, Alexander E, He, Fang, Malik, Ahmed M, Glineburg, Mary Rebecca, Green, Katelyn M, Natla, Sam, Flores, Brittany N, Krans, Amy, Archbold, Hilary C, Fedak, Stephen J, Barmada, Sami J, Todd, Peter K
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2019
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6726903/
https://ncbi.nlm.nih.gov/pubmed/31347257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201847498
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