CGG Repeat associated non-AUG translation utilizes a cap-dependent, scanning mechanism of initiation to produce toxic proteins

Repeat associated non-AUG (RAN) translation produces toxic polypeptides from nucleotide repeat expansions in the absence of an AUG start codon and contributes to neurodegenerative disorders such as ALS and Fragile X Tremor/Ataxia Syndrome (FXTAS). How RAN translation occurs is unknown. Here we defin...

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發表在:Mol Cell
Main Authors: Kearse, Michael G., Green, Katelyn M., Krans, Amy, Rodriguez, Caitlin M., Linsalata, Alexander E., Goldstrohm, Aaron C., Todd, Peter K.
格式: Artigo
語言:Inglês
出版: 2016
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4854189/
https://ncbi.nlm.nih.gov/pubmed/27041225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.02.034
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