Ribosome queuing enables non-AUG translation to be resistant to multiple protein synthesis inhibitors

Aberrant translation initiation at non-AUG start codons is associated with multiple cancers and neurodegenerative diseases. Nevertheless, how non-AUG translation may be regulated differently from canonical translation is poorly understood. Here, we used start codon-specific reporters and ribosome pr...

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: Kearse, Michael G., Goldman, Daniel H., Choi, Jiou, Nwaezeapu, Chike, Liang, Dongming, Green, Katelyn M., Goldstrohm, Aaron C., Todd, Peter K., Green, Rachel, Wilusz, Jeremy E.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2019
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6601509/
https://ncbi.nlm.nih.gov/pubmed/31171704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.324715.119
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