DDX3X and specific initiation factors modulate FMR1 repeat‐associated non‐AUG‐initiated translation

A CGG trinucleotide repeat expansion in the 5′ UTR of FMR1 causes the neurodegenerative disorder Fragile X‐associated tremor/ataxia syndrome (FXTAS). This repeat supports a non‐canonical mode of protein synthesis known as repeat‐associated, non‐AUG (RAN) translation. The mechanism underlying RAN tra...

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Detalhes bibliográficos
Publicado no:EMBO Rep
Main Authors: Linsalata, Alexander E, He, Fang, Malik, Ahmed M, Glineburg, Mary Rebecca, Green, Katelyn M, Natla, Sam, Flores, Brittany N, Krans, Amy, Archbold, Hilary C, Fedak, Stephen J, Barmada, Sami J, Todd, Peter K
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6726903/
https://ncbi.nlm.nih.gov/pubmed/31347257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201847498
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