Proteasome inhibition disrupts the metabolism of fumarate hydratase- deficient tumors by downregulating p62 and c-Myc

Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) is characterized by germline mutations of the FH gene that encodes for the TCA cycle enzyme, fumarate hydratase. HLRCC patients are at risk for the development of an aggressive form of type 2 papillary renal cell carcinoma. By studying the m...

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Pubblicato in:Sci Rep
Autori principali: Sourbier, Carole, Ricketts, Christopher J., Liao, Pei-Jyun, Matsumoto, Shingo, Wei, Darmood, Lang, Martin, Railkar, Reema, Yang, Youfeng, Wei, Ming-Hui, Agarwal, Piyush, Krishna, Murali, Mitchell, James B., Trepel, Jane B., Neckers, Len, Linehan, W. Marston
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6895110/
https://ncbi.nlm.nih.gov/pubmed/31804603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-55003-2
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