Proteasome inhibition disrupts the metabolism of fumarate hydratase- deficient tumors by downregulating p62 and c-Myc

Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) is characterized by germline mutations of the FH gene that encodes for the TCA cycle enzyme, fumarate hydratase. HLRCC patients are at risk for the development of an aggressive form of type 2 papillary renal cell carcinoma. By studying the m...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Sci Rep
Autores principales: Sourbier, Carole, Ricketts, Christopher J., Liao, Pei-Jyun, Matsumoto, Shingo, Wei, Darmood, Lang, Martin, Railkar, Reema, Yang, Youfeng, Wei, Ming-Hui, Agarwal, Piyush, Krishna, Murali, Mitchell, James B., Trepel, Jane B., Neckers, Len, Linehan, W. Marston
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6895110/
https://ncbi.nlm.nih.gov/pubmed/31804603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-55003-2
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares