Targeting ABL1-mediated Oxidative Stress Adaptation in Fumarate Hydratase-Deficient Cancer

Patients with germline fumarate hydratase (FH) mutation are predisposed to develop aggressive kidney cancer with few treatment options and poor therapeutic outcomes. Activity of the proto-oncogene ABL1 is upregulated in FH-deficient kidney tumors and drives a metabolic and survival signaling network...

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Veröffentlicht in:Cancer Cell
Hauptverfasser: Sourbier, Carole, Ricketts, Christopher J., Matsumoto, Shingo, Crooks, Daniel R., Liao, Pei-Jyun, Mannes, Philip Z., Yang, Youfeng, Wei, Ming-Hui, Srivastava, Gaurav, Ghosh, Sanchari, Chen, Viola, Vocke, Cathy D., Merino, Maria, Srinivasan, Ramaprasad, Krishna, Murali C., Mitchell, James B., Pendergast, Ann Marie, Rouault, Tracey A., Neckers, Len, Linehan, W. Marston
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4386283/
https://ncbi.nlm.nih.gov/pubmed/25490448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2014.10.005
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