Proteasome inhibition disrupts the metabolism of fumarate hydratase- deficient tumors by downregulating p62 and c-Myc

Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) is characterized by germline mutations of the FH gene that encodes for the TCA cycle enzyme, fumarate hydratase. HLRCC patients are at risk for the development of an aggressive form of type 2 papillary renal cell carcinoma. By studying the m...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Sci Rep
Egile Nagusiak: Sourbier, Carole, Ricketts, Christopher J., Liao, Pei-Jyun, Matsumoto, Shingo, Wei, Darmood, Lang, Martin, Railkar, Reema, Yang, Youfeng, Wei, Ming-Hui, Agarwal, Piyush, Krishna, Murali, Mitchell, James B., Trepel, Jane B., Neckers, Len, Linehan, W. Marston
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2019
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6895110/
https://ncbi.nlm.nih.gov/pubmed/31804603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-55003-2
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak