Fumarate Hydratase Deficiency in Renal Cancer Induces Glycolytic Addiction and Hypoxia-Inducible Transcription Factor 1α Stabilization by Glucose-Dependent Generation of Reactive Oxygen Species

Hereditary leiomyomatosis and renal cell cancer (HLRCC) is an inherited cancer syndrome linked to biallelic inactivation of the gene encoding the tricarboxylic acid cycle enzyme fumarate hydratase (FH). Individuals with HLRCC are at risk to develop cutaneous and uterine leiomyomas and an aggressive...

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Hauptverfasser: Sudarshan, Sunil, Sourbier, Carole, Kong, Hye-Sik, Block, Karen, Romero, Vladimir A. Valera, Yang, Youfeng, Galindo, Cynthia, Mollapour, Mehdi, Scroggins, Bradley, Goode, Norman, Lee, Min-Jung, Gourlay, Campbell W., Trepel, Jane, Linehan, W. Marston, Neckers, Len
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2009
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2715796/
https://ncbi.nlm.nih.gov/pubmed/19470762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00483-09
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