Fibrogenic Activity of MECP2 Is Regulated by Phosphorylation in Hepatic Stellate Cells

BACKGROUND & AIMS: Methyl-CpG binding protein 2, MECP2, which binds to methylated regions of DNA to regulate transcription, is expressed by hepatic stellate cells (HSCs) and is required for development of liver fibrosis in mice. We investigated the effects of MECP2 deletion from HSCs on their tr...

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Pubblicato in:Gastroenterology
Autori principali: Moran-Salvador, Eva, Garcia-Macia, Marina, Sivaharan, Ashwin, Sabater, Laura, Zaki, Marco Y.W., Oakley, Fiona, Knox, Amber, Page, Agata, Luli, Saimir, Mann, Jelena, Mann, Derek A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: W.B. Saunders 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6853276/
https://ncbi.nlm.nih.gov/pubmed/31352003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2019.07.029
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