CSB interacts with BRCA1 in late S/G2 to promote MRN- and CtIP-mediated DNA end resection

CSB, a member of the SWI2/SNF2 superfamily, has been implicated in evicting histones to promote the DSB pathway choice towards homologous recombination (HR) repair. However, how CSB promotes HR repair remains poorly characterized. Here we demonstrate that CSB interacts with both MRE11/RAD50/NBS1 (MR...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Batenburg, Nicole L, Walker, John R, Coulombe, Yan, Sherker, Alana, Masson, Jean-Yves, Zhu, Xu-Dong
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2019
Témata:
Genome Integrity, Repair and Replication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847465/
https://ncbi.nlm.nih.gov/pubmed/31501894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz784
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