Transcriptional responses to IFN-γ require Mediator kinase-dependent pause release and mechanistically distinct functions of CDK8 and CDK19

Transcriptional responses to external stimuli remain poorly understood. Using GRO-Seq and PRO-Seq, we show that CDK8 kinase activity promotes RNA polymerase II pause release in response to IFN-γ, a universal cytokine involved in immunity and tumor surveillance. The Mediator kinase module contains CD...

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Publicat a:Mol Cell
Autors principals: Steinparzer, Iris, Sedlyarov, Vitaly, Rubin, Jonathan D., Eislmayr, Kevin, Galbraith, Matthew D., Levandowski, Cecilia B., Vcelkova, Terezia, Sneezum, Lucy, Wascher, Florian, Amman, Fabian, Kleinova, Renata, Bender, Heather, Andrysik, Zdenek, Espinosa, Joaquin M., Superti-Furga, Giulio, Dowell, Robin D., Taatjes, Dylan J., Kovarik, Pavel
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6842433/
https://ncbi.nlm.nih.gov/pubmed/31495563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.07.034
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