CDK8 Kinase Phosphorylates Transcription Factor STAT1 to Selectively Regulate the Interferon Response

Gene regulation by cytokine-activated transcription factors of the signal transducer and activator of transcription (STAT) family requires serine phosphorylation within the transactivation domain (TAD). STAT1 and STAT3 TAD phosphorylation occurs upon promoter binding by an unknown kinase. Here, we s...

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Hauptverfasser: Bancerek, Joanna, Poss, Zachary C., Steinparzer, Iris, Sedlyarov, Vitaly, Pfaffenwimmer, Thaddäus, Mikulic, Ivana, Dölken, Lars, Strobl, Birgit, Müller, Mathias, Taatjes, Dylan J., Kovarik, Pavel
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cell Press 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3580287/
https://ncbi.nlm.nih.gov/pubmed/23352233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2012.10.017
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