CDK8 Kinase Phosphorylates Transcription Factor STAT1 to Selectively Regulate the Interferon Response

Gene regulation by cytokine-activated transcription factors of the signal transducer and activator of transcription (STAT) family requires serine phosphorylation within the transactivation domain (TAD). STAT1 and STAT3 TAD phosphorylation occurs upon promoter binding by an unknown kinase. Here, we s...

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Detalhes bibliográficos
Main Authors: Bancerek, Joanna, Poss, Zachary C., Steinparzer, Iris, Sedlyarov, Vitaly, Pfaffenwimmer, Thaddäus, Mikulic, Ivana, Dölken, Lars, Strobl, Birgit, Müller, Mathias, Taatjes, Dylan J., Kovarik, Pavel
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3580287/
https://ncbi.nlm.nih.gov/pubmed/23352233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2012.10.017
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