Context-Dependent IL-1 mRNA-Destabilization by TTP Prevents Dysregulation of Immune Homeostasis Under Steady State Conditions

The bioavailability of the major pro-inflammatory cytokines IL-1α and IL-1β is tightly controlled by transcription and post-translational processing to prevent hyperinflammation. The role of mRNA decay in maintenance of physiological IL-1 amounts remained unknown. Here we show that the down-regulati...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Sneezum, Lucy, Eislmayr, Kevin, Dworak, Helene, Sedlyarov, Vitaly, Le Heron, Anita, Ebner, Florian, Fischer, Irmgard, Iwakura, Yoichiro, Kovarik, Pavel
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7358311/
https://ncbi.nlm.nih.gov/pubmed/32733464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.01398
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