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Matriptase-mediated cleavage of EpCAM destabilizes claudins and dysregulates intestinal epithelial homeostasis

Congenital tufting enteropathy (CTE) is a severe autosomal recessive human diarrheal disorder with characteristic intestinal epithelial dysplasia. CTE can be caused by mutations in genes encoding EpCAM, a putative adhesion molecule, and HAI-2, a cell surface protease inhibitor. A similar phenotype o...

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Bibliografische gegevens
Gepubliceerd in:J Clin Invest
Hoofdauteurs: Wu, Chuan-Jin, Feng, Xu, Lu, Michael, Morimura, Sohshi, Udey, Mark C.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical Investigation 2017
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5272188/
https://ncbi.nlm.nih.gov/pubmed/28094766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI88428
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