Structural insights into mutagenicity of anticancer nucleoside analog cytarabine during replication by DNA polymerase η

Cytarabine (AraC) is the mainstay chemotherapy for acute myeloid leukemia (AML). Whereas initial treatment with AraC is usually successful, most AML patients tend to relapse, and AraC treatment-induced mutagenesis may contribute to the development of chemo-resistant leukemic clones. We show here tha...

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Publicado en:Sci Rep
Main Authors: Rechkoblit, Olga, Johnson, Robert E., Buku, Angeliki, Prakash, Louise, Prakash, Satya, Aggarwal, Aneel K.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6841716/
https://ncbi.nlm.nih.gov/pubmed/31704958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-52703-7
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