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Translesion synthesis DNA polymerases η, ι, and ν promote mutagenic replication through the anticancer nucleoside cytarabine

Cytarabine (AraC) is the mainstay for the treatment of acute myeloid leukemia. Although complete remission is observed in a large proportion of patients, relapse occurs in almost all the cases. The chemotherapeutic action of AraC derives from its ability to inhibit DNA synthesis by the replicative p...

詳細記述

保存先:
書誌詳細
出版年:J Biol Chem
主要な著者: Yoon, Jung-Hoon, Roy Choudhury, Jayati, Prakash, Louise, Prakash, Satya
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2019
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6916505/
https://ncbi.nlm.nih.gov/pubmed/31685662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.011381
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