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Structural insights into mutagenicity of anticancer nucleoside analog cytarabine during replication by DNA polymerase η
Cytarabine (AraC) is the mainstay chemotherapy for acute myeloid leukemia (AML). Whereas initial treatment with AraC is usually successful, most AML patients tend to relapse, and AraC treatment-induced mutagenesis may contribute to the development of chemo-resistant leukemic clones. We show here tha...
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| Publicat a: | Sci Rep |
|---|---|
| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group UK
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6841716/ https://ncbi.nlm.nih.gov/pubmed/31704958 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-52703-7 |
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