Structural basis for cisplatin DNA damage tolerance by human polymerase η during cancer chemotherapy

A major clinical problem in the use of cisplatin to treat cancers is tumor resistance. DNA polymerase η (Polη) is a key polymerase that allows cancer cells to cope with cisplatin–DNA adducts formed during chemotherapy. We present here a structure of human Polη inserting dCTP opposite a cisplatin int...

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Autori principali: Ummat, Ajay, Rechkoblit, Olga, Jain, Rinku, Choudhary, Jayati R., Johnson, Robert E., Silverstein, Timothy D., Buku, Angeliki, Lone, Samer, Prakash, Louise, Prakash, Satya, Aggarwal, Aneel K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3502009/
https://ncbi.nlm.nih.gov/pubmed/22562137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2295
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