טוען...
Structural basis for cisplatin DNA damage tolerance by human polymerase η during cancer chemotherapy
A major clinical problem in the use of cisplatin to treat cancers is tumor resistance. DNA polymerase η (Polη) is a key polymerase that allows cancer cells to cope with cisplatin–DNA adducts formed during chemotherapy. We present here a structure of human Polη inserting dCTP opposite a cisplatin int...
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| Main Authors: | , , , , , , , , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2012
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3502009/ https://ncbi.nlm.nih.gov/pubmed/22562137 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2295 |
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