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Structural basis for polymerase η–promoted resistance to the anticancer nucleoside analog cytarabine
Cytarabine (AraC) is an essential chemotherapeutic for acute myeloid leukemia (AML) and resistance to this drug is a major cause of treatment failure. AraC is a nucleoside analog that differs from 2′-deoxycytidine only by the presence of an additional hydroxyl group at the C2′ position of the 2′-deo...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6107656/ https://ncbi.nlm.nih.gov/pubmed/30140014 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-30796-w |
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