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Structural basis for the suppression of skin cancers by DNA polymerase η
DNA polymerase η (Polη) is unique among eukaryotic polymerases in its proficient ability for error-free replication through UV induced cyclobutane pyrimidine dimers, and inactivation of Polη in humans causes the variant form of xeroderma pigmentosum (XPV). We present the crystal structures of yeast...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3030469/ https://ncbi.nlm.nih.gov/pubmed/20577207 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature09104 |
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