Structural basis for error-free replication of oxidatively damaged DNA by yeast DNA polymerase η

7,8-dihydro-8-oxoxguanine (8-oxoG) adducts are formed frequently by the attack of oxygen FREE radicals on DNA. They are amongst the most mutagenic lesions in cells because of their dual coding potential, where, in addition to normal base-pairing of 8-oxoG(anti) with dCTP, 8-oxoG in the syn conformat...

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Main Authors: Silverstein, Timothy D., Jain, Rinku, Johnson, Robert E., Prakash, Louise, Prakash, Satya, Aggarwal, Aneel K.
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3044447/
https://ncbi.nlm.nih.gov/pubmed/21070945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2010.08.019
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