Human DNA polymerase η is pre-aligned for dNTP binding and catalysis

Pre-steady state kinetic studies on Y-family DNA polymerase η (Polη) have suggested that the polymerase undergoes a rate-limiting conformational change step before the phosphoryl transfer of the incoming nucleotide to the primer terminus. However, the nature of this rate-limiting conformational chan...

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Main Authors: Ummat, Ajay, Silverstein, Timothy D., Rinku, Jain, Buku, Angeliki, Johnson, Robert E., Prakash, Louise, Prakash, Satya, Aggarwal, Aneel K.
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3265613/
https://ncbi.nlm.nih.gov/pubmed/22154937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.11.038
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