CRISPR-Cas12a Nucleases Bind Flexible DNA Duplexes without RNA/DNA Complementarity

[Image: see text] Cas12a (also known as “Cpf1”) is a class 2 type V-A CRISPR-associated nuclease that can cleave double-stranded DNA at specific sites. The Cas12a effector enzyme comprises a single protein and a CRISPR-encoded small RNA (crRNA) and has been used for genome editing and manipulation....

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Detalhes bibliográficos
Publicado no:ACS Omega
Main Authors: Jiang, Wei, Singh, Jaideep, Allen, Aleique, Li, Yue, Kathiresan, Venkatesan, Qureshi, Omair, Tangprasertchai, Narin, Zhang, Xiaojun, Parameshwaran, Hari Priya, Rajan, Rakhi, Qin, Peter Z.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2019
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6811856/
https://ncbi.nlm.nih.gov/pubmed/31656887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.9b01469
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