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The bridge helix of Cas12a imparts selectivity in cis-DNA cleavage and regulates trans-DNA cleavage

Cas12a is an RNA-guided DNA endonuclease of the type V-A CRISPR-Cas system that has evolved convergently with the type II Cas9 protein. We previously showed that proline substitutions in the bridge helix (BH) impart target DNA cleavage selectivity in Streptococcus pyogenes (Spy) Cas9. Here, we exami...

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Xehetasun bibliografikoak
Argitaratua izan da:FEBS Lett
Egile Nagusiak: Parameshwaran, Hari Priya, Babu, Kesavan, Tran, Christine, Guan, Kevin, Allen, Aleique, Kathiresan, Venkatesan, Qin, Peter Z., Rajan, Rakhi
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2021
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC8044059/
https://ncbi.nlm.nih.gov/pubmed/33523494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1873-3468.14051
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