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Bridge helix of Cas9 modulates target DNA cleavage and mismatch tolerance

CRISPR-Cas systems are RNA-guided nucleases that provide adaptive immune protection for bacteria and archaea against intruding genomic materials. The programmable nature of CRISPR targeting mechanisms has enabled their adaptation as powerful genome engineering tools. Cas9, a type II CRISPR effector...

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Detalhes bibliográficos
Publicado no:Biochemistry
Main Authors: Babu, Kesavan, Amrani, Nadia, Jiang, Wei, Yogesha, S.D., Nguyen, Richard, Qin, Peter Z., Rajan, Rakhi
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6496953/
https://ncbi.nlm.nih.gov/pubmed/30916546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b01241
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