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Bridge helix of Cas9 modulates target DNA cleavage and mismatch tolerance
CRISPR-Cas systems are RNA-guided nucleases that provide adaptive immune protection for bacteria and archaea against intruding genomic materials. The programmable nature of CRISPR targeting mechanisms has enabled their adaptation as powerful genome engineering tools. Cas9, a type II CRISPR effector...
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| Veröffentlicht in: | Biochemistry |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6496953/ https://ncbi.nlm.nih.gov/pubmed/30916546 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b01241 |
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