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Distinct patterns of Cas9 mismatch tolerance in vitro and in vivo
Cas9, a CRISPR-associated RNA-guided nuclease, has been rapidly adopted as a tool for biochemical and genetic manipulation of DNA. Although complexes between Cas9 and guide RNAs (gRNAs) offer remarkable specificity and versatility for genome manipulation, mis-targeted events occur. To extend the und...
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| I publikationen: | Nucleic Acids Res |
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| Huvudupphovsmän: | , , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
Oxford University Press
2016
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4914125/ https://ncbi.nlm.nih.gov/pubmed/27198218 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw417 |
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