Target-dependent nickase activities of CRISPR-Cas nucleases Cpf1 and Cas9

Clustered regularly interspaced short palindromic repeat (CRISPR) machineries are prokaryotic immune systems that have been adapted as versatile gene editing and manipulation tools. We found that CRISPR-Cas nucleases Cpf1 (also known as Cas12a) and Cas9 exhibit differential guide RNA sequence requir...

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Udgivet i:Nat Microbiol
Main Authors: Hua Fu, Becky Xu, Smith, Justin D., Fuchs, Ryan T., Mabuchi, Megumu, Curcuru, Jennifer, Robb, G. Brett, Fire, Andrew Z.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6512873/
https://ncbi.nlm.nih.gov/pubmed/30833733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41564-019-0382-0
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